منابع مشابه
Targeted cancer therapy: review article
Cancer is one of the most dangerous health problems of today modern societies which has an increasing rate especially in developing countries. There are many diverse ongoing treatment attempts trying to defeat cancer. Despite that, scientists have been unable to find a permanent cure for this disease. In many cases although there is a successful first response in patients, cancer cells are fina...
متن کاملTargeted Therapy in Breast Cancer.
Currently targeted drug selection in breast cancer is exclusively based on estrogen receptor (ER), progesterone receptor (PgR) and human epidermal growth factor receptor (HER2) expression mainly of the primary tumor, even if metastatic disease is actually treated. Retrospective data indicate discordance regarding those factors between primary tumors and corresponding metastatic lesions in up to...
متن کاملTargeted therapy for HER2 positive breast cancer
INTRODUCTION Breast cancer is the second most common cause of death for women behind lung cancer and the most common cause of cancer deaths for women aged 45-55 years old (CDC.gov 2012). Although there continue to be enormously large numbers of disease incidence, deaths have been declining due to the disease with two hallmark time frames. The first occurred during the mid to late 1980's when ho...
متن کاملTargeted Therapy for Breast Cancer Prevention
With a better understanding of the etiology of breast cancer, molecularly targeted drugs have been developed and are being testing for the treatment and prevention of breast cancer. Targeted drugs that inhibit the estrogen receptor (ER) or estrogen-activated pathways include the selective ER modulators (tamoxifen, raloxifene, and lasofoxifene) and aromatase inhibitors (AIs) (anastrozole, letroz...
متن کاملTargeted Therapy of Breast Cancer.
improve the efficacy of antihormonal therapy and may overcome endocrine treatment resistance at least temporarily in many patients. However, the impressive array of possible treatment combinations and sequences warrants an enormous amount of further research to identify optimal treatment algorithms. Further research will also have to focus on the exploration and establishment of predictive fact...
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ژورنال
عنوان ژورنال: The American Journal of Pathology
سال: 2013
ISSN: 0002-9440
DOI: 10.1016/j.ajpath.2013.07.005